Thursday, October 17, 2019

Caveolin protein Essay Example | Topics and Well Written Essays - 250 words

Caveolin protein - Essay Example l of three (3) variants known as the caveloin-1 (CAV-1), caveolin-2 (CAV-2), and caveolin-3 (CAV-3) (Gussak and Antezelevitch 234; Williams and Lisanti). CAV-1 and CAV-2 can be found in most cells whereas CAV-3 can be found in muscle cells of the heart (Yuan, Garcia and Hales 275). Having a complete sequence status, the size of amino acid length of CAV-1 is 178 (UniProtKB). As a 21- to 24-kDa protein, CAV-1 is composed of 16 amino acids longer than CAV-2 and additional N-terminal 27 amino acids as compared to CAV-3 (Fielding 177). CAV-1 has two variants known as CAV-1ÃŽ ± (contains amino acid tyrosin 14) and CAV-1ÃŽ ² (does not contain the â€Å"first 31 amino acid present in CAV 1ÃŽ ±) (Mercier, Jasmin and Lisanti 18). Both CAV-1ÃŽ ± and 1ÃŽ ² can be found in the lungs whereas CAV-1ÃŽ ² can be found in the epithelial cells (Yuan, Garcia and Hales 275). With regards to internalization of the material, Garcia and Hales (275) explained that CAV-1 can be phosphorylated in â€Å"Rab4-labelled, Rab5-labelled or the early endosome antigen-1-labelled compartments which then subsequently move to the Rab11-associated compartment†. Tang, ZhaoLan, Philipp E. Scherer, Takashi Okamoto, et al. "Molecular cloning of caveolin-3, a novel member of the caveolin gene family expressed predominantly in muscle." Journal of Biological Chemistry 271.4 (1996):

Business communication Coursework Example | Topics and Well Written Essays - 250 words

Business communication - Coursework Example Considering that communication takes place either verbally or non-verbal such as office memos, reports, legal documents; our choices of words and phrases, tone of the speaker’s voice, as well as our gestures, facial expression and body movements when we communicate with other people reflect our own personality. The same theory and concept applies in business communication. Basically, the use of short paragraphs that is well organized and logical reflects the speaker’s characteristics in terms of being a very organized and logical person. In case the speaker is found of using positive words, the audiences will have the impression that the speaker is optimistic in life. For example: A business communicator who does not have the ability to discuss the subject matter straight to the point is likely to send message to his/her audiences that he/she does not have a clear idea on what he/she is discussing. As a result, the audiences are expected to lose their trust and loyalty with the business

Wednesday, October 16, 2019

Caveolin protein Essay Example | Topics and Well Written Essays - 250 words

Caveolin protein - Essay Example l of three (3) variants known as the caveloin-1 (CAV-1), caveolin-2 (CAV-2), and caveolin-3 (CAV-3) (Gussak and Antezelevitch 234; Williams and Lisanti). CAV-1 and CAV-2 can be found in most cells whereas CAV-3 can be found in muscle cells of the heart (Yuan, Garcia and Hales 275). Having a complete sequence status, the size of amino acid length of CAV-1 is 178 (UniProtKB). As a 21- to 24-kDa protein, CAV-1 is composed of 16 amino acids longer than CAV-2 and additional N-terminal 27 amino acids as compared to CAV-3 (Fielding 177). CAV-1 has two variants known as CAV-1ÃŽ ± (contains amino acid tyrosin 14) and CAV-1ÃŽ ² (does not contain the â€Å"first 31 amino acid present in CAV 1ÃŽ ±) (Mercier, Jasmin and Lisanti 18). Both CAV-1ÃŽ ± and 1ÃŽ ² can be found in the lungs whereas CAV-1ÃŽ ² can be found in the epithelial cells (Yuan, Garcia and Hales 275). With regards to internalization of the material, Garcia and Hales (275) explained that CAV-1 can be phosphorylated in â€Å"Rab4-labelled, Rab5-labelled or the early endosome antigen-1-labelled compartments which then subsequently move to the Rab11-associated compartment†. Tang, ZhaoLan, Philipp E. Scherer, Takashi Okamoto, et al. "Molecular cloning of caveolin-3, a novel member of the caveolin gene family expressed predominantly in muscle." Journal of Biological Chemistry 271.4 (1996):

Tuesday, October 15, 2019

Composers of the 20th Century Essay Example | Topics and Well Written Essays - 750 words - 1

Composers of the 20th Century - Essay Example The first and most important way by which Stravinsky did this is by introducing the changing face of his style of composition, while retaining essential and distinctive identity. Stravinsky also introduced the use of motivic development. This involved the use of repeatable musical figures in different guises either in a section of the composition, or in its entirety. Herein, notes are added or subtracted to a motif, without any regard to consequent changes that may take place in metre (20). It is against the backdrop of Stravinsky’s contributions that the idea and practice of pushing rhythms across the bar lines began to gain more notoriety. Consequently, because of Stravinsky’s input, the rhythmic structure in music gained a more fluid and spontaneous streak, especially in his work on The Rite of Spring. The same also made Stravinsky’s compositions take on a more offbeat, primitive and rhythmic drive and thereby making his work more unique. The veracity behind this is underscored by the fact that it is through this effort that Stravinsky is known in the history of music as the only composer who upgraded music to its artistic status. In equal length, Arnold Schoenberg also broke ranks with musical traditions of the past by the many inventions and contributions he made. Particularly, Schoenberg invented the dodecaphonic compositional method which is also known as the twelve-tone compositional method. In so doing, Schoenberg set the path for his students such as Anton Webern, Alban Berg and Hans Eisler who followed the dodecaphonic method of composition and made it famous. Byron points out that Schoenberg showed a departure from the musical traditions of the past by abandoning key centers in his musical composition, and thereby helping perpetuate the concept of free atonality which was relatively new by then (7). Also, Schoenberg’s work and procedures at it were organized in a dual manner, simultaneously. Schoenberg’s

The US failure in Vietnam Essay Example for Free

The US failure in Vietnam Essay Examine the view that the US failure in Vietnam resulted more from losing the hearts and minds of the American people than from military defeats The US failure resulted more from losing the hearts and minds of the American people than from military defeat due to many reasons such as the Tet Offensive and ruthlessness in Napalm, My Lai, etc. However, there were other factors such as the loss of confidence by Johnsons administration and the communist popularity and ingenuity that also resulted in the US failure in Vietnam. One of the main reasons the Americans could not defeat the communists is because they were unable to win the hearts and minds of American people. Americas inability to distinguish the enemy meant that their tactics did not work and led to further failure. My Lai on 16th March 1968 was an example of American hatred of the Vietnamese. 347 unharmed civilians were beaten and killed by American soldiers and their officers. Women were beaten and shot and water was contaminated by buffalo, pigs and chickens being dropped in wells. Generally, the Americans were better at winning the hearts and minds however they were ruthless when necessary. Operation Phoenix was introduced whereby thousands of Vietcongs were sought out and interrogated. Few of these came out alive. This shows that torture was normal and that there was a lack of military tactics and the extent the Americans would go to find out who the enemies were. Moreover, the ruthlessness of Napalm and its victims who were melted into a kind of gelatine and some of who were disfigured lived in caves and remote areas. Also Agent Orange which was used to defoliate 20% of South Vietnams jungles so the enemy could be seen more easily had a tremendous impact; there were incidents of cancer and toxic related diseases which still remains high in Vietnam. Therefore due to all the torturous methods and killings, the US lost the hearts and minds of the American people. America was unable to win the war as their attitudes to the Vietnamese made it difficult to. They never really understood any of the Vietnamese people and classed them as less than human. Furthermore, Americas failure was due to the actions of both Washington and Saigon frequently antagonising the South Vietnamese peasants. Once the Americans entered Vietnam life for the South Vietnamese went from bad to worse. American bombing and Diems strategic hamlets programme forced many peasants to move away and away from the things which meant a lot to them such as crops. Johnson usually tried to avoid targeting non-combatants; however this was difficult as they never knew who their enemies were. However, due to the Americans fighting a Comfortable war, the soldiers became unmotivated and ineffective. American army officers were less experienced than some soldiers he commanded and unpopular officers were shot. It was therefore hard to win the war with so many inexperienced and increasingly unpopular officers. Moreover, the average age of a Grunt in Vietnam was 19 which made them vulnerable. Many shot themselves in the foot or hoped for a small wound, but they never felt safe. Any time Americans or ARVN moved out of an area, the communists would move in. There were a lot of booby traps which wounded 20% of American victims. There were many traps as such which blew away limbs and resulted in huge explosions. The trouble for the Americans was that they never knew which Vietnamese was the enemy, which also was demoralising as they didnt want to hurt innocent victims. Therefore it was hard to win the war when Grunts were demoralised and terrified which links to losing the hearts and minds of the American people. Furthermore, over 8 million volunteered to serve in the army as they were inspired by a sense of duty, patriotism, family tradition or a sense that communism should be stopped. Many wanted to learn new skills such as fighting or enjoyed the war (found it fun to fight, the drama and heroics). Others enjoyed killing other men, but this always attracted the army. However, there was a lack of realism as there were bad soldiers who were not properly trained for the war. This helps to explain why these men were unable to defeat the communists. The Navy did not like taking orders from Westmorelands ground army and they did not get along. The soldiers did not believe in what they were doing and disagreed with tactics. There were a higher proportion of black soldiers who were combat troops rather than doing desk jobs which shows the racial discrimination of the US. Therefore this links to losing the hearts and minds of the Americans and many back individuals would not support the US for doing such things. Furthermore, there were discipline problems; $10,000 reward for the death of the officer responsible for Hamburger Hill. Additionally, there was an anti-war feeling at home which was lowering morale. There was lack of motivation therefore the men were not going to do well and they were not fighting properly therefore they were not going to win. However, the communists on the other hand, had high motivation and they knew what they were fighting for unlike the US. Many soldiers never actually fought in the war, they had to organise the American lifestyle for everyone else. Westmoreland said that the only way soldiers would fight is by a comfortable war which would be motivating. This was important as the communists had ideological motivation unlike the Americans. Army discipline was a problem due to drugs, STDs, prostitution, which led to problems in battle. Many soldiers were dent to Saigon or Japan for RR. Lots of children were fathered by Americans. Overall, everything was made to feel comfortable and the US bribed its soldiers. But they just felt soft. The US openly admitted that their strategies were wrong and that they should have targeted the North. There was a search and destroy mission to clear out any VC. There was only 1% success and there was mostly children casualties. There was a huge fall in morale because as soon as the US cleared an area, the VC would be there, therefore there were no gains. This also links to the poor hearts and minds feeling of American people as many children were being killed. Also, the VC could tell when the US were approaching as they used hi-tech weapons which did not suit Guerrilla Warfare. Moreover, another reason that the US failed in Vietnam was due to communist popularity and ingenuity. The VC won the admiration from American foes as they were inspired by communism and nationalism. They went through a lot of trauma such as skin diseases. This helped the communists win as they out laughed the Americans and proved that they could put up with anything. Furthermore, the battle of la Drang was a good illustration of communist determination and it helped insure ultimate victory. There was a network of tunnels set up underground where the VC could hide, shelter and regroup. Both sides thought they won. However the US could not cope with 300 of their men dying therefore they lost morale, even though the VC lost more men. This links to the morale at home as people were dying which links to losing the hearts and minds of American people. As there were underground communist organisations, the communists knew when they would attack therefore they were one step ahead of the US and they could deal with it in advance. In addition, Saigon became an unsavoury city in the US war years. This made the country weaker and weakened the army and there was a negative impact of US on Saigon. Due to drugs and prostitution, the Vietnamese could not concentrate on the war as much as they were concentrating on what Americans were doing. Overall, US failure in Vietnam resulted more from losing the hearts and minds of the American people than from military defeats because what it came down to in the end was the support the US lacked as their tactics were not working and they were killing innocent victims as they never knew who their enemy was. US failure in Vietnam was also due to communist popularity and ingenuity and the fact that they knew what they were fighting for and had the knowledge of Vietnam that the US lacked. Therefore, although the failure in Vietnam was due to military defeat, it was more from losing the hearts and minds as people were unmotivated.

Monday, October 14, 2019

Links Between Investment in Infrastructure and Job Creation

Links Between Investment in Infrastructure and Job Creation Sourav Roy (13060242044) Sourav Das (13060242043) Saptarshi Maiti (13060242036) Devika Kannan (13060242013) Executive summary The effective tool to create jobs is counter-cyclical spending on infrastructure. As the demand for private sector is weak, the government helps the people with jobs and also aggregate demand. Investments of infrastructure are divided into two parts: Economic sectors include increasing efficiency in transportation, including roads, railways and waterways, Social sectors such as education, water and sewage system. Investments in a local scenario and their impact on development strategies lead to creation of more jobs, greater ownership, and can rapidly boost up the local economies. This is particularly applicable in times of crisis. Decentralized public investment should be favored where ever possible. It is very important to assess the resultant labour output of these investments with respect to its impact on direct as well as indirect and employment, not only to assess their productivity in short run, but also to assess the long run impact on growth and other subsidiary effects. There are number of infrastructure projects in low and medium-income countries which are financed fully or partially by IFI. Institutions like these should make an effort to allow for larger labour participation in infrastructure development. Fiscal decentralization can be defined as a two-dimensional policy: 1). Decentralization of tax instrument. 2). Decentralization of expenditure. The relation between decentralization and government efficiency can be divided into two large areas: a) The classical theory: There are three main contribution where this theory can be restricted, those are Tiebout’s model of local public good provision where decentralization coupled with mobile households solve the problem of the efficient provision of public goods. The second most influential contribution is of Oates’(1972) Decentralization Theorem that involves the tradeoff between centralized and decentralized provision of public goods in favour of former if average preferences across citizen of different region are equal. The theorem stresses on to maximize social welfare. And the last is Leviathan hypothesis where it shows the mechanism for constraining the expansionary tendencies of government mechanism. b) The second generation theory: The effect of fiscal decentralization has been modeled to embody the political process and the possibility of asymmetric information across political agents. Description of Policy Challenges According to the paper, on an average major percentage of total stimuli package in infrastructure is spent in emerging economies as compared to developed economies. The policy-brief paper tried to link infrastructure spending to job creation across economies. In this section the paper mentioned the main challenge of gestation period of the infrastructure projects. It viewed the time differential in processing of such projects as a challenge, as it failed to produce the expected outcomes on the stipulated time during a crisis situation. It later pointed out how infrastructures in different areas bear different results. Infrastructural Investment in rural area created more jobs than in urban areas as the jobs in rural areas are more labour intensive. It said, â€Å"The policy challenge is to match the targeting of infrastructure investments with the targeting of employment creation, be it by category or geographic area.† It explained the challenge with the help of examples of policies in three economies: USA, Indonesia and Egypt. The paper said that in USA infrastructure expenses consists only a minor portion of the total fiscal stimulus. According to the paper, expenditures on infrastructure accumulated up to 30 September 2009 amounted to US$4.44 billion or 2.6 per cent of the total fiscal stimulus during the period. However, according to a few articles in Forbes and Bloomberg Obama is planning to spend highly on infrastructure like science research and education and upgrade bridges, ports and roads to create more jobs. (Runningen, 2013) (Lenzner, 2011). The amount spent by USA in infrastructure is huge but, if we consider the share of infrastructure in GDP is only 2.4%. In USA American Recovery and Reinvestment Act was passed in 2009 which was a stimulus package to help recover the country from the Great Recession. The Act followed Keynesian macroeconomics wherein high public expenditure was necessary for improving the unemployment condition and further economic deterioration. USA’s planned stimulus package after revision was 831 billion dollars and according to Paul Krugman it was too less though he was supportive of the law. (Nobel Laureate Paul Krugman: Too Little Stimulus in Stimulus Plan, 2009) Some of the critics for this policy said that it was too slow and had a huge price tag but according to the data the policy had resulted in decrease in unemployment as the unemployment rate is around 6and half percentage points lower. (Blinder Zandi, 2010) The policy paper further gave examples of Indonesian and Egyptian stimulus package. The Indonesian Government spent 7.6 billion dollars to boost aggregate demand and this spending on infrastructure was 17% of the GDP. Estimation of the government to set a job creation target of over one million workers was surpassed. As for the Egyptian government the stimulus package was worth 2.82 billion dollar in the financial year 2008-09. According to various estimates it stated that the complete stimulus package is expected to create between 661,420 and 729,650 new job opportunities. This section of the policy paper concluded by mentioning that some amount of public expenditure (read infrastructure spending) is good as it helps in growth and development of economy through skill development of the labour and promotion of SMEs (Small and Medium Enterprises). It further wrote â€Å"spending cuts in such forms of investment would have a serious negative impact on employment and recovery unless ways could be found to maintain services with reduced costs.† Policy Options to address the challenge The examples illustrated above clearly reflect the issues related to the number of jobs created and the targeting of different sections of labour force. The focus of policy making in this area should shift from the amount of money spent to the number of jobs created relative to the set of employable workers and to the amount of public services provided. A prolonged strategy needs to be developed whose objective would be to provide short term relief from unemployment and long term creation of jobs aiming to meet the structural infrastructure deficits. Measures to guarantee timely implementation Higher public spending in periods of crisis for job creation involves a lag which is inherent in the cycle of identifying, formulating and approving projects. Therefore, objective should be a speedy and timely implementation, as an economy which is already in recession can deteriorate even quickly. The rate at which jobs can be created depends on the type of projects (large construction projects versus small or medium maintenance projects). Another important factor which determines the pace of the projects is the distribution of public tender procedures. A number of countries experience effective execution of public investment at less than 50% of the amount budgeted. Therefore, the short term objective is to achieve full execution of available resources rather than just allocation of additional resources. In order to ensure the timely implementation and to reap benefits from the existing administrational structures, public work schemes can be given additional funds to scale up. Taking up planned infrastructure and improving the efficiency of implementation of works formulated in public investment programmes are few of the features of the fiscal stimulus package. Decentralization of standard administrative procedures and dividing them into small grants at local levels to employ small-scale local contractors, labourers and local resources to efficiently enhance the employment opportunities of the infrastructure component of the packages is often a more effective than centrally planned and executed projects. Targeting Traditionally, the options of targeting were limited in public investment programmes, since majority of the works were generally executed by private enterprises. As objectives of targeting can be influenced to a certain degree through innovations to procurement systems hence, Public Employment Programmes, in which special targeting mechanisms can be applied, play an important complementary role. An important means of targeting constitutes the prioritization of investment projects in areas most affected by crisis. Subcontracting small works to local labourers allows for the targeting of special groups, such as women. In regular maintenance activities, women may take a larger share of job opportunities. Impact of infrastructure spending An investment in infrastructure is the first stepping stone towards the long run development and also takes into account immediate social needs. Generally, investments in infrastructure includes those in economic, such as, improving transportation viz. roads, railways and waterways and social sectors, such as health and education, treatment of water and sewage, and other public sectors. These investments depend mostly on the urgent requirements of the country. A major part of these expenditures can be executed through small-scale or medium-scale enterprises and thereby promoting them. Investments in infrastructure with a focus on the employment have a strong employment multiplier effect, since it leads to job creation both directly and indirectly. Increased usage of local goods and services creates a high indirect employment effect, which in turn leads to higher local incomes and thereby stimulates the local demand and consumption. However, this has to be taken cautiously as the way a job is defined varies from one country to another. There is no valid way to measure the direct employment created because of the fiscal stimulus package, as most countries face problems in gathering reliable data. Therefore, we need a consolidated effort to improving our way of understanding and documentation of the effects, in order to provide better guidance on the measures where the effects of multiplier are most prominent, given the requirements of the particular country. Conclusion Investments in infrastructure should be launched to build up capital for sustainable development and inclusive growth: human capital including skills, employment (including green jobs) and entrepreneurship development, and physical capital such as construction, rehabilitation and maintenance of infrastructure. As told earlier decentralized public investment should be preferred:- First, because decentralized decision-making processes are faster and local population more committed to the projects. It improves targeting and its proper use and maintenance. Secondly, the works undertaken are usually on a smaller scale and involve less expensive tenders, which mean there is less need for heavy machinery. Third, decentralized tenders are more likely to be executed by local firms using workers from the area, thus boosting the local economy as a whole. Because many infrastructure projects in low and medium countries are co- financed by international financial institutions, these institutions should make sure that their regulations allow for an increase in labour content in infrastructure development. Readjusting the design, procurement and contracting modalities of such products could have a major effect on employment. Works Cited Blinder, A. S., Zandi, M. (2010, December). Stimulas Worked. Retrieved from www.imf.org: https://www.imf.org/external/pubs/ft/fandd/2010/12/blinder.htm Council-on-Foreign-Relations. (2014, March 4). Infrastructure. Retrieved from www.cfr.org: http://www.cfr.org/infrastructure/infrastructure/p26178 Lenzner, R. (2011, October 23). A $1.2 Trillion Infrastructure Plan Creates 27 Million Jobs In 5 Years. Retrieved from www.forbes.com: http://www.forbes.com/sites/robertlenzner/2011/10/23/the-u-s-wont-be-able-to-grow-again-until-2016-18/ Nobel Laureate Paul Krugman: Too Little Stimulus in Stimulus Plan. (2009, February 19). Retrieved from http://knowledge.wharton.upenn.edu/article/nobel-laureate-paul-krugman-too-little-stimulus-in-stimulus-plan/ Runningen, R. (2013, November 9). Obama Urges Infrastructure Spending to Spur U.S. Economy. Retrieved from www.bloomberg.com: http://www.bloomberg.com/news/2013-11-09/obama-urges-infrastructure-spending-to-spur-u-s-economy.html Spending on transport infrastructure: Latest Data Released. (2013, July 11). Retrieved from www.internationaltransportforum.org: http://www.internationaltransportforum.org/Press/PDFs/2013-07-11Spending.pdf

Sunday, October 13, 2019

Tennis Made Easy :: essays research papers

When surfing the Internet, eventually winding up at tennis4you.com, I found something called the â€Å"Lesson Lounge† which has instructional articles on the game of tennis. My particular article discusses a very crucial part of the game, and also a difficult one, the first serve. The reason this drew my attention is because this is a major weakness in my already pathetic tennis repertoire. By reading the article, I hoped to find strategy to learn from, and eventually, with practice, to improve from. In the article, they explain how the first serve can become â€Å"†¦someone’s biggest weapon making someone else’s worst nightmare!† That, not only can one use a power serve or a placement serve to attack their opponents, but that working out is not even necessary to do so. The tennis serve can have significantly more power by using â€Å"†¦legs, shoulder rotation, and stomach muscles†¦Ã¢â‚¬  during one’s motion. They stress that since you have two serves, it is crucial to take a chance and make sure your first serve is NOT â€Å"†¦easily attackable†. From here, they lead into more complicated serving techniques that involve the type of hit- such as the flat, slice, kick, and topspin serves. Although I am not good enough to test them out, through time, they could certainly help someone with an interest in tennis who is willing to practice. After establishing the four types, the writer goes more in depth to differences between power and non-power serves. With power serves, they emphasize the importance of rhythm, significance of keeping your opponent guessing and lastly, the need to hit it in bounds. They continue to say that, obviously, no matter how hard your serve is, it is useless if it cannot land in bounds. As far as non-power serves, they speak of smaller players and how technique and mechanisms such as spin. Another main point here is that one must serve deep into the service box.